Discovery of New Autoimmune Disease: Otulipenia

Otulipenia is a rare and sometimes fatal inflammatory disease that causes fever, skin rashes, diarrhea and joint pain in young children. The NIH research team discovered that it is caused by a genetic defect that interrupts the processing of an important immune system protein, ubiquitin, resulting in the inflammation. It was determined that helpful medications for this condition are TNF inhibitors which are used to treat other chronic inflammatory diseases such as rheumatoid arthritis. The malfunction of this protein had not previously been linked to immune disorders and the discovery opens new therapy options for other inflammatory diseases. Click here to learn more.